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KMID : 0378019840270020103
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New Medical Journal
1984 Volume.27 No. 2 p.103 ~ p.110
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A study on the effect of Ritodrine Hydrochloride on preterm labor, fetus and neonate
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徐浩錫/Suh, H.S.
曺洙鎔/Chough, S.Y.
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Abstract
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Although perinatal mortality figures have been improving, it has been the result of a decline in age-specific, or weight specific mortality. The incidence of delivery at low birth weight scarcely has declined.
Attention to these problems has turned us to make an effort for prevention or treatment of preterm labor.
A clinical study was conducted for the evaluation of effectiveness of Ritrodrine Hydrochloride on preterm labor from Jan. 1982 to Dec. 1983 in the Armed Forces Seoul District General Hospital and Guro-Hospital, affiliated to College of Medicine, Korea University.
A total of 58 cases of preterm labor was entered into this study, of which 43 cases were
treated with Ritrodrine and 15 cases were with placebo for a control group.
Most studies had been focused on inhibition rather than prevention of preterm labor.
The result of this study were as follows:
1. There were no statistically significant difference in clinical characteristics; maternal age, gravity, parity, gestational age, cervical dilatation, initial maternal heart rate, blood pressure and mean tocolysis score.
2. Labor was successfully postponed beyond the treatment period in 26 cases (76.5%) of 34 cases with intact membranes, who were treated with Ritrodine, while in control group, these were seen in 4 cases (36.4%) out of 11 respectively. The difference between the two groups is statistically significant.
3. The mean gain days were 24.8 days in the treated group and 8.5 days in control group with intact menbranes. The difference between the two groups is statistically significant.
4. There was a significant increase in maternal heart rate, slight increase in maternal pulse pressure, but no significant difference in maternal blood pressure and heart rate during Ritrodrine infusion.
5. There was a significant increase in maternal blood glucose and insulin levels with no significant change in maternal potassium level after 2 hours infusion of Rirodrine.
6. There was significant difference in mean weight of infants born before 34 weeks., but no significant difference in 1m and 5m Apgar scores of the new born infants between the treated group and the control.
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